RAF Typhoon FGR4s have joined forces with France's air force in a joint strike against an hidden munitions depot in Syria operated by the Daesh militant organization, as stated by the UK's MoD.
The site, identified by intelligence, was thought to be containing munitions and bombs, the statement said, and was located in hills just north of Palmyra in the heart of Syria.
"Our aircraft employed Paveway IV guided bombs to target a several access tunnels leading to the depot... early reports are that the target was engaged successfully," officials stated.
There was no sign of any harm to civilians in the operation late on Saturday and all the aircraft made a safe return, the MoD added.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
IS - referred to as the so-called Islamic State - established jihadist rule over parts of Iraq and Syria until 2019.
"This operation demonstrates the UK's leading role, and resolve to operate in unison with our allies, to eradicate any resurgence of the terrorist group and their violent and radical beliefs in the region," the British Defence Secretary John Healey remarked.
RAF aircraft have carried out patrols over Syria to "prevent any attempted comeback" of IS following its defeat at the Baghuz confrontation in the year 2019, the MoD reported.
"I extend gratitude to the personnel of the UK armed forces participating in this strike for their skill and their valour," he commented. "Including them were a great many British troops deployed over the holidays. This action, to eliminate dangerous terrorists who endanger our way of life, highlights how British military are prepared to act, all year round, ensuring Britain's security domestically and powerful internationally."
In December, the US military conducted what it called a "major assault" on IS targets in Syria, after an assault resulted in the deaths of two US servicemembers and a local interpreter in the Palmyra area.
The UN says Islamic State still has roughly 5-7 thousand fighters in Syria and Iraq.